Some Additional Observations on the Specificity of Cholinesterase
نویسنده
چکیده
As an extension of previous investigations (1, 2) concerning the specificity of cholinesterase, the present study deals with the effect upon enzymatic hydrolysis of variations in the chain length of the acid component of choline esters. It is known from earlier work (3, 1) that increasing the normal chain length from 2 to 4 carbon atoms results in increased cnzymatic and decreased alkaline splitting. However, nothing has been reported concerning the hydrolysis of the successively higher members of the series. It was shown (1) that the dZ-caproyl+-methylcholine chloride is hydrolyzed, enzymatically, over 4 t’imes as fast as the corresponding acetyl ester, while the latter undergoes nonenzymatic scission at a rate over 4 times that of the former. In the same communication it was reported that isovaleryl-fl-dimethyl-y-homocholine iodide was hydrolyzed over 3 times as fast as the corresponding acetyl derivative, while the non-enzymatic splitting of the latter was about 1.5 times that of the former. In this paper the preparation and hydrolysis of the esters of the normal 5-, 6-, and 7-carbon acids will be described as well as the succinic and maleic acid derivatives. Of these, to the author’s knowledge, only valerylcholine has been prepared previously. The P-bromoethyl esters serving as intermediates for the preparation of the choline esters have not been described before, and these as well as the choline ester chloroplatinates have also been prepared.
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